For all we know currently, for all that we could potentially know as a human species, or even some kind of advanced super futuristic super neo-humans, if we make it that far, there are some great questions that may end up being so beyond our comprehension that we’ll likely never be able to answer them. Questions about the nature of reality, the existence or non-existence of god-like multi-dimensional, incomprehensible intelligences, the permanence of some kind of self before and after birth and death, etc. Ya know, the biggies. 

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